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Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells

2023-10-19

Abstract excerpt

Ribosomal DNA (rDNA) genes encode the structural RNAs of the ribosome and are present in hundreds of copies in mammalian genomes. Age-linked DNA hypermethylation throughout the rDNA constitutes a robust “methylation clock” that accurately reports age, yet the consequences of hypermethylation on rDNA function are unknown. We confirmed that pervasive hypermethylation of rDNA occurs during mammalian aging and senesce...

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Literature Corpus work
0cbcc3ba-69ff-50e3-9fe2-f918f1798ea7
DOI
10.1101/2023.10.18.562830
Open publication

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Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cellsDOI 10.1101/2023.10.18.562830
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