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Article

Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.

Nature communications - 13 Aug 2021

Capella Matías, Mandemaker Imke K, Martín Caballero Lucía, den Brave Fabian, Pfander Boris, Ladurner Andreas G, Jentsch Stefan, Braun Sigurd

Abstract excerpt

Ribosomal RNA genes (rDNA) are highly unstable and susceptible to rearrangement due to their repetitive nature and active transcriptional status. Sequestration of rDNA in the nucleolus suppresses uncontrolled recombination. However, broken repeats must be first released to the nucleoplasm to allow repair by homologous recombination. Nucleolar release of broken rDNA repeats is conserved from yeast to humans, but...

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Identifiers

PMID: 34389719
DOI: 10.1038/s41467-021-25205-2
PMCID: PMC8363623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.PMID 34389719Read ↗

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