Article

Protein UFMylation regulates early events of ribosomal DNA double-stranded break response

2024-02-14

Abstract excerpt

<h4>ABSTRACT</h4> The highly repetitive and transcriptionally active ribosomal DNA (rDNA) genes are exceedingly susceptible to genotoxic stress. Induction of DNA double-strand breaks (DSBs) in rDNA repeats is associated with ATM-dependent rDNA silencing and nucleolar reorganization where rDNA is segregated into nucleolar caps. However, the regulatory events underlying this response remain elusive. Here, we identi...

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Literature Corpus work: fe7aae8f-bf28-554b-ad82-b9c04b89ee6a
DOI: 10.1101/2024.02.14.580383

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