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Recent advances in the nucleolar responses to DNA double-strand breaks

26 Aug 2020

Abstract excerpt

DNA damage poses a serious threat to human health and cells therefore continuously monitor and repair DNA lesions across the genome. Ribosomal DNA is a genomic domain that represents a particular challenge due to repetitive sequences, high transcriptional activity and its localization in the nucleolus, where the accessibility of DNA repair factors is limited. Recent discoveries have significantly extended our...

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PMID: 32857853
DOI: 10.1093/nar/gkaa713

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