Article

Simulating Protein Structure to Support Clinical Decisions: Predicting the Ligand Specific Impact of Genomic Variation on Opioid Binding

2020-10-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Predicting the impact of missense protein variants on drug binding would have a widespread implications on the practice of genomic medicine, including matching a molecular therapy and dosage to an individual’s genome sequence. Genetic variation is widespread within G-protein-coupled receptors, which can affect overall structure and conformation of the receptors....

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Literature Corpus work: 84b26265-f147-5927-a730-6bc5a418c7aa
DOI: 10.21203/rs.3.rs-87124/v1

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