Article

High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

2024-10-12

Abstract excerpt

Deep Mutational Scanning (DMS) is an emerging method to systematically test the functional consequences of thousands of sequence changes to a protein target in a single experiment. Because of its utility in interpreting both human variant effects and protein structure-function relationships, it holds substantial promise to improve drug discovery and clinical development. However, applications in this domain requir...

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Literature Corpus work: b5be85c3-37d0-55d5-b86a-23e5d91bda37
DOI: 10.1101/2024.10.11.617882

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