Article
Combating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design.
Expert opinion on drug discovery - 1 Jun 2017
Albanaz Amanda T S, Rodrigues Carlos H M, Pires Douglas E V, Ascher David B
Abstract excerpt
INTRODUCTION: Mutations introduce diversity into genomes, leading to selective changes and driving evolution. These changes have contributed to the emergence of many of the current major health concerns of the 21st century, from the development of genetic diseases and cancers to the rise and spread of drug resistance. The experimental systematic testing of all mutations in a system of interest is impractical and...
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