Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of protein mutations on drug binding suggests ensuing personalised drug selection.

Scientific reports - 29 Jun 2021

Wan Shunzhou, Kumar Deepak, Ilyin Valentin, Al Homsi Ussama, Sher Gulab, Knuth Alexander, Coveney Peter V

Abstract excerpt

The advent of personalised medicine promises a deeper understanding of mechanisms and therefore therapies. However, the connection between genomic sequences and clinical treatments is often unclear. We studied 50 breast cancer patients belonging to a population-cohort in the state of Qatar. From Sanger sequencing, we identified several new deleterious mutations in the estrogen receptor 1 gene (ESR1). The effect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Hormonal
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Mutation

Share to Neoplasm Proteins

Share to Precision Medicine

Source

Open in PubMed Open full text

Identifiers

PMID: 34188094
DOI: 10.1038/s41598-021-92785-w
PMCID: PMC8241852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of protein mutations on drug binding suggests ensuing personalised drug selection.PMID 34188094Read ↗

Structural insights into conformational stability of ESR1 and structure base screening of new potent inhibitor for the treatment of Breast CancerSemantic proximity Read ↗

Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes.Semantic proximity Read ↗

Simulating Protein Structure to Support Clinical Decisions: Predicting the Ligand Specific Impact of Genomic Variation on Opioid BindingSemantic proximity Read ↗

Prediction Of The Impact Of Genetic Variability On Drug Sensitivity For Clinically Relevant EGFR MutationsSemantic proximity Read ↗

[Effect of ESR1 Somatic Mutations on SERM/SERD Binding: Insights from Molecular Docking and Molecular Dynamics Simulations].Semantic proximity Read ↗

A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers.Semantic proximity Read ↗

PremPLI: Predicting the Effects of Missense Mutations on Protein-Ligand InteractionsSemantic proximity Read ↗

Molecular Modeling Studies to Probe the Binding Hypothesis of Novel Lead Compounds against Multidrug Resistance Protein ABCB1Semantic proximity Read ↗

Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.Semantic proximity Read ↗

Structural evolution of the estrogen receptor regulatory domainSemantic proximity Read ↗

Personalized prediction of EGFR mutation-induced drug resistance in lung cancer.Semantic proximity Read ↗

Computational Analysis of MDR1 Variants Predicts Effect on Cancer Cells via their Effect on mRNA Folding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.