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Article

Characterizing clinically relevant natural variants of GPCRs using computational approaches.

Methods in cell biology - 1 Jan 2017

Sengupta Durba, Sonar Krushna, Joshi Manali

Abstract excerpt

G protein-coupled receptors (GPCRs) are an important class of drug targets owing to their physiological role. A large number of clinically relevant single nucleotide polymorphisms (SNPs) have been observed in GPCRs that are linked to disease susceptibility and adverse drug response. It is therefore important to characterize the variants in order to improve GPCR therapeutics. Here, we discuss computational methods...

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Identifiers

PMID: 28964336
DOI: 10.1016/bs.mcb.2017.07.013

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