Article

PremPLI: Predicting the Effects of Missense Mutations on Protein-Ligand Interactions

2021-05-10

Abstract excerpt

<title>Abstract</title> <p>Protein-ligand interactions trigger a multitude of signal transduction processes and resistance to small-molecule drugs is the main cause of the failure of therapeutic drugs in clinical practice. Missense mutations altering the binding of ligands to proteins are one of the critical mechanisms that result in genetic disease and drug resistance. Computational methods have made a lot of pr...

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Literature Corpus work: 57d3c89d-1631-5930-922d-a07ba54dca8c
DOI: 10.21203/rs.3.rs-417047/v1

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