Article

Towards Generalizable Predictions for the Effects of Mutations on G-Protein Coupled Receptor Expression

2021-12-28

Abstract excerpt

<h4>ABSTRACT</h4> Missense mutations that compromise the plasma membrane expression (PME) of integral membrane proteins (MPs) are the root cause of numerous genetic diseases. Differentiation of this class of mutations from those that specifically modify the activity of the folded protein has proven useful for the development and targeting of precision therapeutics. Nevertheless, it remains challenging to predict...

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Literature Corpus work: 6a51ca64-127a-5046-b8d4-218e2122ef1c
DOI: 10.1101/2021.12.28.474371

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