Article

Phenotype Scoring of Population Scale Single-Cell Data Dissects Alzheimer’s Disease Complexity

2024-11-02

Abstract excerpt

The complexity of Alzheimer’s disease (AD) manifests in diverse clinical phenotypes, including cognitive impairment and neuropsychiatric symptoms (NPSs). However, the etiology of these phenotypes remains elusive. To address this, the PsychAD project generated a population-level single-nucleus RNA-seq dataset comprising over 6 million nuclei from the prefrontal cortex of 1,494 individual brains, covering a variety...

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Literature Corpus work: 84a4a24d-871a-53a5-9d1f-31af0a85b0f5
DOI: 10.1101/2024.11.01.24316586

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