Article

Stabilizing selection of seasonal influenza receptor binding in populations with partial immunity

2020-06-29

Abstract excerpt

Mutations that alter cellular receptor binding of influenza hemagglutinin (HA) have profound effects on immune escape. Despite its high mutation rate, it is not fully understood why human influenza HA displays limited antigenic diversity across circulating viruses. We applied phylogenetic analysis and phylodynamic modeling to understand the evolutionary and epidemiological effects of binding avidity adaptation in...

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Literature Corpus work: 84a0de8b-128b-5342-9cb5-57edadabdbec
DOI: 10.1101/2020.06.27.175190

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