Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamics of glycoprotein charge in the evolutionary history of human influenza.

PloS one - 30 Dec 2010

Arinaminpathy Nimalan, Grenfell Bryan

Abstract excerpt

BACKGROUND: Influenza viruses show a significant capacity to evade host immunity; this is manifest both as large occasional jumps in the antigenic phenotype of viral surface molecules and in gradual antigenic changes leading to annual influenza epidemics in humans. Recent mouse studies show that avidity for host cells can play an important role in polyclonal antibody escape, and further that electrostatic charge...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Protein
Share to Epidemics
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune System

Share to Influenza A Virus, H3N2 Subtype

Share to Influenza, Human

Share to Neuraminidase

Share to Viruses

Source

Open in PubMed Open full text

Identifiers

PMID: 21209885
DOI: 10.1371/journal.pone.0015674
PMCID: PMC3012697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamics of glycoprotein charge in the evolutionary history of human influenza.PMID 21209885Read ↗

Implications of localized charge for human influenza A H1N1 hemagglutinin evolution: Insights from deep mutational scans.Semantic proximity Read ↗

Stabilizing selection of seasonal influenza receptor binding in populations with partial immunitySemantic proximity Read ↗

Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancingSemantic proximity Read ↗

Compensatory Evolution of Net-Charge in Influenza A Virus HemagglutininSemantic proximity Read ↗

Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancingSemantic proximity Read ↗

Epistasis facilitates the long-term antigenic evolution of the influenza B virus hemagglutininSemantic proximity Read ↗

Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutininSemantic proximity Read ↗

Charged amino acid variability related to N-glyco -sylation and epitopes in A/H3N2 influenza: Hem -agglutinin and neuraminidase.Semantic proximity Read ↗

Neuraminidase antigenic drift of Influenza A virus H3N2 clade 3c.2a viruses alters virus replication, enzymatic activity and inhibitory antibody bindingSemantic proximity Read ↗

Changing Selective Pressure during Antigenic Changes in Human Influenza H3Semantic proximity Read ↗

The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans.Semantic proximity Read ↗

Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.