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Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs

18 Jan 2018

Abstract excerpt

Rapid antigenic evolution enables the persistence of seasonal influenza A and B viruses in human populations despite widespread herd immunity. Understanding viral mechanisms that enable antigenic evolution is critical for designing durable vaccines and therapeutics. Here, we utilize the primerID method of error-correcting viral population sequencing to reveal an unexpected role for hemagglutinin (HA)...

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PMID: 29346435
DOI: 10.1371/journal.ppat.1006796

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