Article

Mutations in <i>TAC1B</i> : a novel genetic determinant of clinical fluconazole resistance in <i>C. auris</i>

2020-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, yet it remains unknown what mechanisms underpin this fluconazole resistance. To identify novel mechanisms contributing to fluconazole resistance in C. auris , the fluconazole-susceptib...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 849a8c96-95b4-56d3-ade9-3b267a347988
DOI: 10.1101/2020.02.18.955534

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutations in <i>TAC1B</i> : a novel genetic determinant of clinical fluconazole resistance in <i>C. auris</i>DOI 10.1101/2020.02.18.955534Read

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris.Semantic proximity Read

Mutations in <i>TAC1B</i> drive <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>C. auris</i>Semantic proximity Read

Genomic diversity across <i>Candida auris</i> clinical isolates shapes rapid development of antifungal resistance <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

Mutations in TAC1B drive increased CDR1 and MDR1 expression and azole resistance in Candida auris.Semantic proximity Read

A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole Resistance of Candida auris.Semantic proximity Read

Genome-wide analysis of experimentally evolved <i>Candida auris</i> reveals multiple novel mechanisms of multidrug-resistanceSemantic proximity Read

Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in <i>Candida auris</i> , <i>Candida albicans</i> , <i>Candida parapsilosis</i> , and <i>Candida glabrata</i> ( <i>Nakaseomyces glabratus</i> )Semantic proximity Read

Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates.Semantic proximity Read

Short-Term Evolution and Dispersal Patterns of Fluconazole-Resistance in <i>Candida auris</i> clade IIISemantic proximity Read

Rapid in vitro evolution of flucytosine resistance in Candida aurisSemantic proximity Read

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In VivoSemantic proximity Read

Broad sensitivity of <i>Candida auris</i> strains to quinolones and mechanisms of resistanceSemantic proximity Read