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Rapid in vitro evolution of flucytosine resistance in Candida auris

18 Mar 2025

Abstract excerpt

ABSTRACT The pan-antifungal-resistant pathogen Candida auris has been causing high-mortality infection outbreaks in hospitals and healthcare settings. The prodrug 5-fluorocytosine (5FC) is one of four chemical entities, but its clinical use as an antifungal drug has been limited owing to pronounced resistance. However, antifungal combination therapy with 5FC appears as a promising strategy for treating C. auris...

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PMID: 40099908
DOI: 10.1128/msphere.00977-24

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