Article
A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole Resistance of Candida auris.
mSphere - 22 Apr 2020
Mayr Eva-Maria, Ramírez-Zavala Bernardo, Krüger Ines, Morschhäuser Joachim
Abstract excerpt
The recently emerged pathogenic yeast Candida auris is a major concern for human health, because it is easily transmissible, difficult to eradicate from hospitals, and highly drug resistant. Most C. auris isolates are resistant to the widely used antifungal drug fluconazole due to mutations in the target enzyme Erg11 and high activity of efflux pumps, such as Cdr1. In the well-studied, distantly related yeast...
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