Article
Mutations in TAC1B drive increased CDR1 and MDR1 expression and azole resistance in Candida auris.
Antimicrobial agents and chemotherapy - 1 Oct 2025
Barker Katherine S, Santana Darian J, Zhang Qing, Peters Tracy L, Rybak Jeffrey M, Morschhäuser Joachim, Cuomo Christina A, Rogers P David
Abstract excerpt
Candida auris has emerged as a fungal pathogen of particular concern owing in part to its propensity to exhibit antifungal resistance, especially to the commonly prescribed antifungal fluconazole. A mutation in TAC1B, which encodes a zinc cluster transcription factor, has been shown to confer increased resistance to fluconazole. In this work, we aimed to determine how mutations in TAC1B exert this effect. TAC1B...
Topics
Join the communities discussing this publication.