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Mutations in ERG11, TAC1B, and CDR1 reduce fluconazole accumulation in drug-resistant Candidozyma auris isolates.

mBio - 11 Mar 2026

Esquivel Brooke D, Santos Amanda, Rybak Jeffrey M, Santana Darian J, Rogers P David, White Theodore C

Abstract excerpt

Fluconazole (FLC)-resistant Candidozyma auris isolates have reduced drug accumulation compared to azole-susceptible isolates. Of 119 C. auris isolates, 83 out of 87 resistant isolates (~95%) had extremely low fluconazole uptake, whereas 30 out of 32 susceptible isolates (~93%) had high fluconazole uptake. In search of a genetic explanation for this phenomenon, we compared metadata for TAC1B and CDR1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41649269
DOI: 10.1128/mbio.03957-25
PMCID: PMC12977551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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