Article

Mutations in <i>TAC1B</i> drive <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>C. auris</i>

2025-02-11

Abstract excerpt

<h4>Objective</h4> Candida auris has emerged as a fungal pathogen of particular concern owing in part to its propensity to exhibit antifungal resistance, especially to the commonly prescribed antifungal fluconazole. In this work we aimed to determine how mutations in the transcription factor gene TAC1B , which are common among resistant isolates and confer fluconazole resistance, exert this effect. <h4>Methods<...

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Literature Corpus work: 4cabab16-1e75-55eb-a28c-35699a437439
DOI: 10.1101/2025.02.11.637698

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