Article

Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease

2017-04-19

Abstract excerpt

Genome-wide association studies have identified hundreds of risk loci for autoimmune disease, yet only a minority (∼25%) share genetic effects with changes to gene expression (eQTLs) in immune cells. RNA-Seq based quantification at whole-gene resolution, where abundance is estimated by culminating expression of all transcripts or exons of the same gene, is likely to account for this observed lack of colocalisation...

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Literature Corpus work: 22cea768-9f1b-5e46-b2a4-e4eb22893104
DOI: 10.1101/128728

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