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Article

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.

Nature genetics - 1 May 2018

Harley John B, Chen Xiaoting, Pujato Mario, Miller Daniel, Maddox Avery, Forney Carmy, Magnusen Albert F, Lynch Arthur, Chetal Kashish, Yukawa Masashi, Barski Artem, Salomonis Nathan, Kaufman Kenneth M, Kottyan Leah C, Weirauch Matthew T

Abstract excerpt

Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. Using new computational methods, we show that transcription factors (TFs) occupy multiple loci associated with individual complex genetic disorders. Application to 213 phenotypes and 1,544 TF binding datasets identified 2,264 relationships between hundreds of TFs and 94...

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Share to Autoimmunity
Share to Epstein-Barr Virus Nuclear Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lupus Erythematosus, Systemic

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Source

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Identifiers

PMID: 29662164
DOI: 10.1038/s41588-018-0102-3
PMCID: PMC6022759

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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