Article
Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs.
JCI insight - 3 Sept 2020
Chen Xiao-Feng, Guo Ming-Rui, Duan Yuan-Yuan, Jiang Feng, Wu Hao, Dong Shan-Shan, Zhou Xiao-Rong, Thynn Hlaing Nwe, Liu Cong-Cong, Zhang Lin, Guo Yan, Yang Tie-Lin
Abstract excerpt
More than 90% of autoimmune-associated variants are located in noncoding regions, leading to challenges in deciphering the underlying causal roles of functional variants and genes and biological mechanisms. Therefore, to reduce the gap between traditional genetic findings and mechanistic understanding of disease etiologies and clinical drug development, it is important to translate systematically the regulatory...
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