Article

Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis

2024-04-12

Abstract excerpt

<h4>Summary</h4> The enteric nervous system (ENS) is contained within two layers of the gut wall and is made up of neurons, immune cells, and enteric glia cells (EGCs) that regulate gastrointestinal (GI) function. EGCs in both inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) change in response to inflammation, referred to as reactive gliosis. Whether EGCs restricted to a specific layer or regio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55e7e8e5-cf05-5227-8ef1-9248e2d35454
DOI: 10.1101/2024.04.09.588619

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosisDOI 10.1101/2024.04.09.588619Read

Neuroimmune Crossroads: The Interplay of the Enteric Nervous System and Intestinal Macrophages in Gut Homeostasis and DiseaseSemantic proximity Read

Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for GI Infection, IBD, POI, Neurological, Motility, and GI Disorders.Semantic proximity Read

From diversity to disease: unravelling the role of enteric glial cellsSemantic proximity Read

Role of microRNAs in Disorders of Gut–Brain Interactions: Clinical Insights and Therapeutic AlternativesSemantic proximity Read

Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation.Semantic proximity Read

Immune dysregulation in the functional gastrointestinal disorders.Semantic proximity Read

The role of mast cells in functional GI disorders.Semantic proximity Read

IL-17 sensitises sensory neurons and colonic afferents to noxious stimuli in a PI3K dependent mannerSemantic proximity Read

Roles of G protein-coupled receptors in inflammatory bowel disease.Semantic proximity Read

Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium ResponsesSemantic proximity Read

Irritable bowel syndrome: emerging paradigm in pathophysiology.Semantic proximity Read

Transcriptional profiling identifies IL-33-expressing intestinal stromal cells as a signaling hub poised to interact with enteric neuronsSemantic proximity Read