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Article

TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP.

Mucosal immunology - 1 May 2015

de Jong P R, Takahashi N, Peiris M, Bertin S, Lee J, Gareau M G, Paniagua A, Harris A R, Herdman D S, Corr M, Blackshaw L A, Raz E

Abstract excerpt

TRPM8 is the molecular sensor for cold; however, the physiological role of TRPM8+ neurons at mucosal surfaces is unclear. Here we evaluated the distribution and peptidergic properties of TRPM8+ fibers in naive and inflamed colons, as well as their role in mucosal inflammation. We found that Trpm8(-/-) mice were hypersusceptible to dextran sodium sulfate (DSS)-induced colitis, and that Trpm8(-/-) CD11c+ DCs...

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Share to Calcitonin Gene-Related Peptide
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25269705
DOI: 10.1038/mi.2014.82
PMCID: PMC4382463

Genes

TRPM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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