Article

An interorgan neuroimmune circuit promotes visceral hypersensitivity

2025-03-17

Abstract excerpt

<title>Abstract</title> <p>Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ systems has remained a mystery. Here, we identify a mast cell-sensory neuron circuit that initiates bladd...

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Literature Corpus work: 36f1b4e7-f795-5de3-b4f4-0d58a011c54f
DOI: 10.21203/rs.3.rs-6221928/v1

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