Article
TRPA1 and substance P mediate colitis in mice.
Gastroenterology - 1 Oct 2011
Engel Matthias A, Leffler Andreas, Niedermirtl Florian, Babes Alexandru, Zimmermann Katharina, Filipović Miloš R, Izydorczyk Iwona, Eberhardt Mirjam, Kichko Tatjana I, Mueller-Tribbensee Sonja M, Khalil Mohammad, Siklosi Norbert, Nau Carla, Ivanović-Burmazović Ivana, Neuhuber Winfried L, Becker Christoph, Neurath Markus F, Reeh Peter W
Abstract excerpt
BACKGROUND & AIMS: The neuropeptides calcitonin gene-related peptide (CGRP) and substance P, and calcium channels, which control their release from extrinsic sensory neurons, have important roles in experimental colitis. We investigated the mechanisms of colitis in 2 different models, the involvement of the irritant receptor transient receptor potential of the ankyrin type-1 (TRPA1), and the effects of CGRP and...
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