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Article

Keratinocyte expression of calcitonin gene-related peptide β: Implications for neuropathic and inflammatory pain mechanisms

19 Jun 2011

Abstract excerpt

Summary In a variety of chronic pain conditions, calcitonin gene-related peptide (CGRP) is expressed at high levels in the skin, blood, and cerebrospinal fluid. Our results reveal that much of the increase may be due to the CGRPβ isoform made by epidermal keratinocytes, which express high levels of CGRP immunoreactivity in a variety of human and animal chronic pain conditions. Calcitonin gene-related peptide...

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PMID: 21641113
DOI: 10.1016/j.pain.2011.04.033

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