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Article

Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets

12 Oct 2016

Abstract excerpt

Tissue damage is usually regarded as a necessary price to pay for successful elimination of pathogens by the innate immune defense. Yet, it is possible to distinguish protective from destructive effects of innate immune activation and selectively attenuate molecular nodes that create pathology. Here, we identify acute cystitis as an Interleukin-1 beta (IL-1β)-driven, hyper-inflammatory condition of the infected...

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PMID: 27732661
DOI: 10.1371/journal.ppat.1005848

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