Progress in targeting the NLRP3 signaling pathway for inflammatory bowel disease (Review)

Abstract excerpt

Inflammatory caspases pro‑inflammatory cytokines, such as IL‑1β IL‑18, constitute a critical part in the modulation of innate immune responses by the nucleotide‑binding domain leucine‑rich repeat protein (NLRP)3 inflammasome. The NLRP3 inflammasome, a cytosolic complex, is composed of three distinct classes of proteins‑sensor complexes, adaptor proteins, cysteine proteases. It is well‑established that this...

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