Article
Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target.
Gastroenterology - 1 Apr 2021
Chen Ernie, Chuang Ling-Shiang, Giri Mamta, Villaverde Nicole, Hsu Nai-Yun, Sabic Ksenija, Joshowitz Sari, Gettler Kyle, Nayar Shikha, Chai Zhi, Alter Isaac L, Chasteau Colleen C, Korie Ujunwa M, Dzedzik Siarhei, Thin Tin Htwe, Jain Aayushee, Moscati Arden, Bongers Gerardus, Duerr Richard H, Silverberg Mark S, Brant Steven R, Rioux John D, Peter Inga, Schumm L Philip, Haritunians Talin, McGovern Dermot P, Itan Yuval, Cho Judy H
Abstract excerpt
BACKGROUND & AIMS: Recent literature has implicated a key role for mast cells in murine models of colonic inflammation, but their role in human ulcerative colitis (UC) is not well established. A major advance has been the identification of mrgprb2 (human orthologue, MRGPX2) as mediating IgE-independent mast cell activation. We sought to define mechanisms of mast cell activation and MRGPRX2 in human UC. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.