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Article

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.

Human molecular genetics - 15 Jun 2011

Estes Patricia S, Boehringer Ashley, Zwick Rebecca, Tang Jonathan E, Grigsby Brianna, Zarnescu Daniela C

Abstract excerpt

The RNA-binding protein TDP-43 has been linked to amyotrophic lateral sclerosis (ALS) both as a causative locus and as a marker of pathology. With several missense mutations being identified within TDP-43, efforts have been directed towards generating animal models of ALS in mouse, zebrafish, Drosophila and worms. Previous loss of function and overexpression studies have shown that alterations in TDP-43 dosage...

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Identifiers

PMID: 21441568
DOI: 10.1093/hmg/ddr124
PMCID: PMC3098735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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