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Article

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism.

Acta neuropathologica communications - 2 Dec 2025

Hogan Alison L, Kane Madison, Chiu Patrick, Richter Grant, Maurel Cindy, Wu Sharlynn, Scherer Natalie M, Don Emily K, Lee Albert, Blair Ian P, Chung Roger S, Morsch Marco

Abstract excerpt

Dysregulation of the TAR DNA-binding protein 43 (TDP-43), including intraneuronal cytoplasmic mislocalisation and aggregation is a feature of multiple neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia (FTLD), limbic-predominant age-related TDP-43 encephalopathy (LATE) and alzheimer’s disease (AD). Unravelling the causes and functional consequences of TDP-43...

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Identifiers

PMID: 41331940
DOI: 10.1186/s40478-025-02159-w
PMCID: PMC12997875

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