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Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines

13 Dec 2018

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disorder that affects both upper and lower motor neurons, leading to muscle atrophy with spasticity and eventual death in 3 to 5 years after the disease onset. More than 50 mutations linked to ALS have been found in the gene TARDBP, encoding the protein TDP-43 that is the predominant component of neuronal inclusions in ALS. TDP-43...

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PMID: 30618614
DOI: 10.3389/fnmol.2018.00463

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Transcriptomic Analysis of Zebrafish TDP-43 Transgenic LinesPMID 30618614Read ↗

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