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Article

TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons.

Annals of neurology - 1 Jan 2026

Harji Ziyaan A, Rampal Christian J, Rodríguez Esteban C, Petel Légaré Virginie, Lissouba Alexandra, Semmler Sabrina, Liao Meijiang, Ross Jay P, Rouleau Guy A, Vande Velde Christine, Armstrong Gary A B

Abstract excerpt

OBJECTIVE: Mutations in TARDBP (encoding TDP-43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic. METHODS: In this study, we developed 2 tardbp (Tdp-43) knock-in (KI) zebrafish mutant models encoding the analogous A382T and G348C variants and investigated...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40862353
DOI: 10.1002/ana.78012
PMCID: PMC12946615

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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