Article

CRISPR-pass: Gene rescue of nonsense mutations using adenine base editors

2019-02-10

Abstract excerpt

A nonsense mutation is a substitutive mutation in a DNA sequence that causes a premature termination during translation and produces stalled proteins resulting in dysfunction of a gene. Although it usually induces severe genetic disorders, there are no definite methods for inducing read-through of premature termination codons (PTCs). Here, we present a targeted tool for bypassing PTCs, named CRISPR-pass that uses...

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Identifiers and source

Literature Corpus work: 84725797-3705-5250-ae3e-db7e9906fa8d
DOI: 10.1101/545723

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