Article
Advances in base editing: A focus on base transversions.
Mutation research. Reviews in mutation research - 1 Jan 2024
Wang Dawei, Zhang YiZhan, Zhang Jinning, Zhao JiaJun
Abstract excerpt
Single nucleotide variants (SNVs) constitute the most frequent variants that cause human genetic diseases. Base editors (BEs) comprise a new generation of CRISPR-based technologies, which are considered to have a promising future for curing genetic diseases caused by SNVs as they enable the direct and irreversible correction of base mutations. Two of the early types of BEs, cytosine base editor (CBE) and adenine...
Topics
- Humans
- Gene Editing
- CRISPR-Cas Systems
- Cytosine
- Polymorphism, Single Nucleotide
- Point Mutation
- Adenine
- Animals