The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAFV600E.

doi:10.1111/bph.15923

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Article

The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAFV600E.

British journal of pharmacology - 1 Oct 2022

Moral-Sanz Javier, Fernandez-Rojo Manuel A, Colmenarejo Gonzalo, Kurdyukov Sergey, Brust Andreas, Ragnarsson Lotten, Andersson Åsa, Vila Sabela F, Cabezas-Sainz Pablo, Wilhelm Patrick, Vela-Sebastián Ana, Fernández-Carrasco Isabel, Chin Yanni K Y, López-Mancheño Yaiza, Smallwood Taylor B, Clark Richard J, Fry Bryan G, King Glenn F, Ramm Grant A, Alewood Paul F, Lewis Richard J, Mulvenna Jason P, Boyle Glen M, Sanchez Laura E, Neely G Gregory, Miles John J, Ikonomopoulou Maria P

Abstract excerpt

BACKGROUND AND PURPOSE: Over past decades, targeted therapies and immunotherapy have improved survival and reduced the morbidity of patients with BRAF-mutated melanoma. However, drug resistance and relapse hinder overall success. Therefore, there is an urgent need for novel compounds with therapeutic efficacy against BRAF-melanoma. This prompted us to investigate the antiproliferative profile of a...

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