Article
5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation.
Cell reports. Medicine - 20 Jan 2026
Li Aicun, Xu Shoujia, Fan Jiachen, Liu Jingwei, Song Xiaoyu, Cao Liu, Gong Zhicheng, Lu Xiao
Abstract excerpt
The dual challenges of limited therapeutic options due to de novo or acquired resistance and psychological distress in patients with melanoma necessitate innovative treatment strategies. Here, we identify paroxetine hydrochloride (PH), a Food and Drug Administration (FDA)-approved antidepressant, as an alternative therapeutic for BRAFV600E-mutated melanoma, including BRAFi/MEKi-resistant cases. Furthermore, our...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.