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Article

MITF reprograms the extracellular matrix and focal adhesion in melanoma

13 Jan 2021

Abstract excerpt

The microphthalmia-associated transcription factor (MITF) is a critical regulator of melanocyte development and differentiation. It also plays an important role in melanoma where it has been described as a molecular rheostat that, depending on activity levels, allows reversible switching between different cellular states. Here, we show that MITF directly represses the expression of genes associated with the...

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PMID: 33438577
DOI: 10.7554/elife.63093

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MITF reprograms the extracellular matrix and focal adhesion in melanomaPMID 33438577Read ↗

MITF reprograms the extracellular matrix and focal adhesion in melanomaSemantic proximity Read ↗

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