Article

MITF reprograms the extracellular matrix and focal adhesion in melanoma

2020-07-15

Abstract excerpt

The microphthalmia associated transcription factor (MITF) is a critical regulator of melanocyte development and differentiation. It also plays an important role in melanoma where it has been described as a molecular rheostat that, depending on activity levels, allows reversible switching between different cellular states. Here we show that MITF directly represses the expression of genes associated with the extrace...

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Literature Corpus work: eda4402f-0b21-522f-a40a-bde4731802e6
DOI: 10.1101/2020.07.14.202291

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