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Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signaling

2026-04-28

Abstract excerpt

Medication-overuse headache (MOH) is one of the leading causes of chronic daily headache worldwide and arises from the repeated use of acute anti-migraine medications, including triptans. However, the cellular substrates and intracellular pathways driving this paradoxical chronification remain unknown. Here, using Schwann cell-selective silencing of the 5-HT 1B/D receptor, we observed that acute triptan administr...

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Identifiers and source

Literature Corpus work
3692393e-b7f6-5d0a-afd7-493fd04b4c08
DOI
10.64898/2026.04.24.720547
Open publication

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Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signalingDOI 10.64898/2026.04.24.720547
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