Article
The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells.
International journal of cancer - 15 Jun 2017
Hegedũs Luca, Garay Tamás, Molnár Eszter, Varga Karolina, Bilecz Ágnes, Török Szilvia, Padányi Rita, Pászty Katalin, Wolf Matthias, Grusch Michael, Kállay Enikõ, Döme Balázs, Berger Walter, Hegedũs Balázs, Enyedi Agnes
Abstract excerpt
Oncogenic mutations of BRAF lead to constitutive ERK activity that supports melanoma cell growth and survival. While Ca2+ signaling is a well-known regulator of tumor progression, the crosstalk between Ca2+ signaling and the Ras-BRAF-MEK-ERK pathway is much less explored. Here we show that in BRAF mutant melanoma cells the abundance of the plasma membrane Ca2+ ATPase isoform 4b (PMCA4b, ATP2B4) is low at baseline...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.