Article
P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b.
Cells - 13 May 2020
Naffa Randa, Vogel Lisa, Hegedűs Luca, Pászty Katalin, Tóth Sarolta, Kelemen Kornélia, Singh Neha, Reményi Attila, Kállay Enikő, Cserepes Mihály, Tóvári József, Grusch Michael, Enyedi Ágnes
Abstract excerpt
Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca2+ pump isoform 4b (PMCA4b or ATP2B4) as a putative metastasis suppressor in BRAF mutant melanoma cells. Metastasis suppressors are often downregulated in cancer, therefore, it is important to identify the pathways involved in their degradation. Here, we studied the role of p38 MAPK in PMCA4b...
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