Article

Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

2026-07-25

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells sense riboflavin metabolites through the monomorphic antigen-presenting molecule MR1, providing a unique opportunity to therapeutically mobilize a broadly shared T cell population without genetic engineering. Here, we show that the highly potent microbial metabolites, 5-OP-RU and 5-OE-RU, can be exploited as pharmacologic precision immune activators to drive human MAIT c...

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Literature Corpus work: 84421a50-28a5-5c24-8525-38fd7c95e929
DOI: 10.64898/2026.07.24.740456

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