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Article

Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries.

Frontiers in immunology - 1 Jan 2020

Corbett Alexandra J, Awad Wael, Wang Huimeng, Chen Zhenjun

Abstract excerpt

Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important, and conserved, immune function. For many years, the antigens they recognize were unknown. The discovery that MR1 presents vitamin B-based small molecule ligands...

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Topics

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Share to Antigen Presentation
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Minor Histocompatibility Antigens

Share to Phenotype

Share to Receptors, Antigen, T-Cell

Share to Riboflavin

Share to Vitamin B Complex

Source

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Identifiers

PMID: 32973800
DOI: 10.3389/fimmu.2020.01961
PMCID: PMC7482426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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