Article

Specific targeting of MR1-antigen complexes using nanobodies

2026-03-25

Abstract excerpt

T cell receptor mimic (TCRm) antibodies and nanobodies that specifically bind peptide-HLA complexes have great therapeutic potential, as they can target polymorphic HLA on tumour cells furnishing peptides derived from tumour-associated antigens. MR1 is an MHC class-I-like molecule that exhibits limited polymorphism that binds and presents conserved metabolites, such as 5-OP-RU, derived from microbial riboflavin bi...

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Literature Corpus work: 1c561f12-ce08-536c-87d8-3ea4a3fd699c
DOI: 10.64898/2026.03.22.713551

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