Article

Targeting the MR1-MAIT Cell Axis Improves Vaccine Efficacy and Affords Protection against Viral Pathogens

2023-02-21

Abstract excerpt

Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like T lymphocytes with tremendous antibacterial and immunomodulatory functions. MAIT cells also sense and respond to viral infections in an MR1-independent fashion. However, whether they can be directly targeted in immunization strategies against viral pathogens is unknown. We addressed this question in multiple wild-type and genetically altere...

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Literature Corpus work: 1d0ca72a-74f2-5de4-a73c-4103dcf7f767
DOI: 10.1101/2023.02.20.529311

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