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Article

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

21 Jul 2014

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) α-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12 in humans), which pairs with an array of TCR β-chains. MAIT TCRs can bind folate- and riboflavin-based metabolites restricted by the major histocompatibility complex (MHC)-related class I-like molecule, MR1. However, the impact of MAIT TCR and MR1-ligand heterogeneity on MAIT...

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PMID: 25049336
DOI: 10.1084/jem.20140484

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